Course name: Toxicological Chemistry
COURSE CONTENT
The course considers the chemistry, the metabolic processes, the toxicities and the mechanisms of action of various classes of toxicants.
Contents: General concepts of toxicology. Chemical nature of toxicants. Biochemical transformations. Biochemical mechanisms of toxicity. Biochemistry of mutagenesis, carcinogenesis and teratogenicity. Main classes of toxicants: toxic elements (metals, metalloids, non metals); toxic inorganic compounds; toxic organometallic and organometalloids; toxic organic compounds; Organooxygen, organonitrogen, organohalide, organosulphur and organophosphorus compounds. Indicators of exposure to xenobiotics. Primary and secondary prevention. Biomarkers
LEARNING OUTCOME
Toxicological chemistry is the chemistry of toxic substances. The course bridges the gap between toxicology and chemistry, emphasizing chemical aspects of toxicological phenomena, including fates and effects of xenobiotic chemicals in biological tissue and living systems. Focusing on quantitative structure-activity relationships by relating the chemical structure and physical characteristics of various compounds to their toxic effects, the course provides the foundation for predicting the toxicological effects of toxicants. Moreover, it allows to gain greater knowledge concerning environment and workplace safety.
CREDITS: 5
CONTACT INFORMATION
Prof. Cristina Marzano
University of Padova
Department of Pharmaceutical Sciences
Via Marzolo 5
35131 Padova
Tel. +39 049 82 75 365
+39 049 82 75 347
Fax +39 049 82 75 366
e-mail:
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