Course name: Analytical Chemistry with Statistical Elements and Analysis of Medicines II
COURSE CONTENT
Introduction to quantitative drug analysis. Safety in the laboratory. Molarity, equivalents, calculus in volumetric analysis. Elements of statistical analysis in the experimental data treatment. Standard solutions.
Volumetric analysis:
Acid-base titrations . Titration curves of acid and bases. Examples according to F.U.
Redox titrations. Permanganometry, Iodimeter, Iodometry, Cerimetry. Examples according to F.U.
Precipitation titrations . Determination of halides by Mohr's, Volhard's methods. Practical aspects, limitations. Examples according to F.U.
Complex-formation titrations employing EDTA. Examples according to F.U.
Instrumental Analysis:
UV-Vis Spectrophotometric analysis: Lambert Beer law, calibration curve construction.
Fluorometry: Excitation and emission spectra. Chemical fluorescence derivatisation of drugs.
Atomic absorption spectroscopy: Quantitative analysis: adding standard methods.
Chromatographic separations. Plate theory. Van Deemter equation. Retention time and capacity factor. HPLC, direct and reversed phase, solvent and elution mode selection. Detectors: Quantitative analysis: internal and external standard methods.
Radiochemical methods.
Extraction separation and quantification of active principles from drug formulations.
LEARNING OUTCOME
The student acquires theoretical and practical knowledge for analytical laboratory work, in particular the goal of this course is to prepare students to be able to plan and execute quantitative drug analysis by means of volumetric titrations and instrumental methodologies (UV-Vis, Fluorometry, Atomic Absorption, HPLC, TLC, etc) and determination and quantification of drugs in pharmaceutical formulations and complex matrices
CREDITS:
Analytical Chemistry with statistical elements: 5 CFU (Lectures)
Analysis of medicines II: 5 CFU (lectures) + 4 CFU (Lab practice)
Total: 14 CFU
CONTACT INFORMATION
Prof. Daniela Vedaldi : tel. 049/8275707, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it Department of Pharmaceutical Sciences, Via Marzolo 5, Ed. B, First Floor.
Office hours: Tuesday and Thursday 10.30-11.30, otherwise upon appointment via phone or e-mail:
Prof. Giorgia Miolo: tel. 049/8275705, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it Department of Pharmaceutical Sciences, Via Marzolo 5, Ed. B, First Floor
Office hours: Monday and Friday 11.30-13.00, otherwise upon appointment via phone or e-mail: